WebApr 4, 2024 · Results: The NRF2 pathway inhibitors decreased NRF2 protein level in A549 and H460 cells by approximately 60%, as measured by western blotting. As a result, NRF2-mediated transcription of cytoprotective genes NQO1, GCLC, GCLM, and AKR1C2 were decreased by 30-60% (p<0.05) by qPCR. WebMar 23, 2024 · Nrf2 target gene products, HO-1 and GCLC proteins, were reduced compared to controls and reduction of Nrf2 gene expression was associated with elevated levels of microRNA-132 and...
Abstract 529: Novel inhibitors of the NRF2 pathway also arrest …
WebNational Center for Biotechnology Information WebFeb 25, 2004 · Because nuclear factor erythroid2-related factor 2 (Nrf2) governs basal and inducible GCLC and GCLM expression by means of the antioxidant response element … tod\\u0027s borse
Frontiers The Role of Natural Products in Targeting …
WebDec 14, 2024 · NRF2 is a master transcription factor that regulates various antioxidant proteins and cytoprotection factors. To examine whether NRF2 pathway activation … WebDec 21, 2016 · NRF2 also controls the expression of glutathione S-transferases (GST) and glutathione peroxidases 2 (GPX2), which are enzymes known for detoxifying epoxide and H 2 O 2, respectively. Additionally, NRF2 also regulates the expression of the solute carrier family 7 member 11 (SLC7A11), which encodes the cystine/glutamate transporter XCT [ … WebJul 25, 2024 · As ML385 is known to effectively block the Nrf2 pathway, we treated cardiomyocytes with 20 μM ML385 to determine whether quercetin inhibited the pyroptosis pathway by inhibiting Nrf2. We found that ML385 significantly inhibited the mRNA expression of the antioxidant factors HO-1 and GCLC in the Nrf2 pathway (Figure 4(a)). tod\\u0027s borsa