WebProduct details CAS Number: 243984-11-4 Purity: ≥98% Formulation: A crystalline solid Molecular Weight: 361.8 Alternative Names: 6r- [ [ (2-chloro-4 … Web3 Jun 2024 · The purpose of this project is to computationally investigate the molecular interaction of TAK-242 and some of its synthetic analogs with TLR4 for inhibiting its …
The Toll‑like receptor 4 antagonist TAK‑242 protects against …
WebSolubility for TAK 242 Preparing Stock Solutions for TAK 242 The following data is based on the product molecular weight 361.82. Batch specific molecular weights may vary from … Web23 Oct 2024 · While TAK-242 was shown to suppress the increase in serum TNF-a, IL-1, and IL-6 in murine and porcine models of sepsis, it had no effect on survival (10, 11). In … english chat room learning english
TAK-242, a Toll-Like Receptor 4 Antagonist, Protects against ...
Web1 Oct 2016 · TAK-242 (resatorvid), a novel small-molecule cyclohexene derivative, inhibits TLR4 signaling selectively. TAK-242 blocked the Toll-like receptor (TLR) 4-triggered … WebResatorvid, also known as TAK-242, is a cell-permeable inhibitor of TLR4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of … Web29 Sep 2010 · TAK-242 (resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. Cys747 in TLR4 has been identified previously as the binding site of TAK-242. english chat free for learning